Institut Curie

4 Jobs

2,782 Employees

About the Company

L’Institut Curie, premier centre français de recherche et de lutte contre le cancer, associe un centre de recherche de renommée internationale et un ensemble hospitalier de pointe qui prend en charge tous les cancers y compris les plus rares. Fondé en 1909 par Marie Curie, l’Institut Curie rassemble sur 3 sites (Paris, Saint-Cloud et Orsay) 3 800 chercheurs, médecins et soignants autour de ses 3 missions : recherche, soins et transmission des savoirs. Fondation reconnue d’utilité publique habilitée à recevoir des dons et des legs, l’Institut Curie peut, grâce au soutien de ses donateurs, accélérer les découvertes et ainsi améliorer les traitements et la qualité de vie des malades.

Listed Jobs

Company Name: Institut Curie
Job Title: Ingénieur.e en radiobiologie (F/H)
Job Description: Job Title: Radiobiology Engineer (F/M) Role Summary: Conduct in‑vivo radiation therapy research, design and execute animal protocols, and analyze biological data to validate novel FLASH‑VHEE radiotherapy technology in a multidisciplinary team. Expectations: 12‑month renewable contract, full‑time, starting spring 2026. Key Responsibilities: • Design and implement in‑vivo experiments, prepare protocols, and submit ethics approvals. • Perform animal handling: intraperitoneal/IP and intravenous/IV injections, weighing, anesthesia, euthanasia, and monitor clinical parameters. • Process and analyze biological samples (genotyping, histology, immunofluorescence, flow cytometry, PCR). • Collect, organize, analyze data, and maintain electronic lab notebooks. • Collaborate with radiotherapists, physicists, postdocs, and clinicians. Required Skills: • Proficiency in animal manipulation techniques (IP/IV injection, anesthesia, euthanasia). • Experience with histology, cytometry, molecular biology (PCR). • Strong scientific rigor, observational skills, critical thinking. • Excellent written and oral communication in French; technical English preferred. • Ability to write protocols and ethics submissions. • Self‑organized, autonomous, and team‑collaborative. Required Education & Certifications: • Minimum Master’s (MSc) or Engineer degree (Bac+5) in Biology, Biotechnology, Life Sciences, or Physiology. • 2–5 years of in‑vivo research experience (internship, apprenticeship, or comparable role). • Specific training in animal experimentation – user level (Category B) required; designer level (Category C) preferred. • Valid French animal experimenter license (Category B) and any additional certification as needed.

Company Name: Institut Curie
Job Title: Postdoctorat en immuno-oncologie (F/H)
Job Description: **Job Title:** Postdoctoral Researcher – Immuno‑Oncology (F/H) **Role Summary:** Conduct independent research to identify and validate tumor‑specific neo‑antigens in non‑small cell lung cancer (NSCLC). Characterize neo‑antigen‑specific T‑cell responses using immunopeptidomics, flow cytometry, single‑cell technologies, tetramer staining, and functional cytotoxicity assays. Collaborate with a multidisciplinary team to generate data supporting translational immunotherapy strategies. **Expectations:** - Deliver high‑quality experimental data within project timelines. - Apply rigorous scientific methodology and maintain detailed documentation. - Analyze and interpret complex immunological datasets, integrating bioinformatic insights when applicable. - Communicate findings effectively in English through reports, presentations, and manuscripts. - Contribute to a collaborative, interdisciplinary team environment. **Key Responsibilities:** - Perform in‑silico neo‑antigen prediction and validate candidates via immunopeptidomics. - Isolate and phenotype tumor‑infiltrating and peripheral T cells using flow cytometry and tetramer labeling. - Execute single‑cell RNA‑seq and related analyses to define T‑cell subsets and states. - Conduct functional assays (e.g., ex vivo cultures, killing assays) to assess T‑cell reactivity and cytotoxicity. - Process and analyze blood and tumor samples from NSCLC patients undergoing immunotherapy. - Maintain laboratory equipment, reagents, and compliance with safety and data integrity standards. - Prepare technical reports, figures, and contribute to scientific publications and conference abstracts. **Required Skills:** - Expert proficiency in flow cytometry (experimental design, panel development, data analysis). - Strong background in human immunology, cancer biology, and immunotherapy concepts. - Hands‑on experience with immunopeptidomics, tetramer assays, and functional cytotoxicity testing. - Familiarity with single‑cell sequencing (library preparation, bioinformatic pipelines) is highly desirable. - Ability to conduct statistical analysis and interpret complex datasets; basic bioinformatics skills a plus. - Excellent analytical, problem‑solving, and scientific writing abilities. - Fluent in English (written and spoken); French not required. - Demonstrated teamwork and proactive, dynamic attitude toward research innovation. **Required Education & Certifications:** - Ph.D. in Immunology, Molecular & Cellular Biology, Biotechnology, or a closely related discipline. - Proven expertise in human immunology and oncology research. - Certification or documented training in flow cytometry is mandatory. - No additional certifications required; eligibility to work in the host country is assumed.

Paris, France

Hybrid

11-02-2026

Company Name: Institut Curie
Job Title: Research Engineer Position (Bioinformatician) NGS Data Analysis in Pediatric Oncology (F/M)
Job Description: **Job Title:** Research Engineer (Bioinformatician), Pediatric Oncology NGS Data Analysis **Role Summary:** Conduct advanced NGS data analysis for pediatric oncology and rare cancers, contributing to translational research and molecular characterization. Collaborate with multidisciplinary teams to develop and optimize bioinformatics workflows. **Expectations:** - Ph.D. in Oncology, Molecular Biology, Biotechnology, or related field. - Minimum 2+ years in NGS data analysis within oncology or translational genomics. **Key Responsibilities:** - Analyze and integrate multi-omics datasets (genomic, transcriptomic, epigenomic) from pediatric and rare cancers. - Develop, optimize, and apply bioinformatics pipelines for NGS data derived from liquid biopsies and solid tumor samples. - Collaborate with biologists, clinicians, and bioinformaticians to interpret data and support scientific dissemination. - Monitor technological advancements in pediatric oncology and NGS methodologies. - Maintain and document standardized analytical workflows to ensure data reproducibility. **Required Skills:** - Proficiency in NGS data formats (FASTQ, BAM, VCF) and analysis tools. - Scripting expertise in Python and R for data processing and statistical analysis. - Familiarity with public genomic databases (e.g., TCGA, GTEx). - Strong understanding of molecular biology and tumor progression mechanisms. **Required Education & Certifications:** - Ph.D. or equivalent in Oncology, Molecular/Cellular Biology, or related disciplines. - Demonstrated research experience in pediatric oncology or cancer genomics.

Paris, France

Hybrid

11-02-2026

Company Name: Institut Curie
Job Title: Ingénieur de rech. (Bioinfo) - Analyse Données NGS, Onco. Pédiatrique (F-H)
Job Description: Job title Research Engineer (Bioinformatics) – NGS Data Analysis, Pediatric Oncology Role Summary Analyze and integrate multi‑omics NGS data from pediatric oncology patients, with a focus on liquid biopsy and rare tumor applications. Develop and optimize robust bioinformatics pipelines, interpret genomic alterations, and contribute to scientific reporting and publications. Expectations * Deliver high‑quality, reproducible analyses within a multidisciplinary research setting. * Maintain and document bioinformatics workflows, ensuring compliance with data governance and reproducibility standards. * Keep up‑to‑date with advances in pediatric oncology, NGS technology, and liquid biopsy methodologies. Key Responsibilities * Integrate and analyze multi‑omics NGS datasets (FASTQ, BAM, VCF, etc.) from patient samples. * Develop, optimize, and apply analytical pipelines for liquid biopsy workflows. * Support, maintain, and document analytical and bioinformatics workflows and pipelines. * Perform literature and technology monitoring in pediatric oncology, NGS platforms, and liquid biopsy techniques. * Interpret data, produce analytical reports, and contribute to manuscript preparation and scientific communications. Required Skills * Proficiency in Python and R for data analysis and statistical modeling. * Familiarity with NGS data formats (FASTQ, BAM, VCF) and variant calling workflows. * Experience with genomic/transcriptomic analysis and interpretation. * Knowledge of public genomic and transcriptomic resources (e.g., TCGA, GTEx, Human Cell Atlas). * Ability to work collaboratively in an international, multidisciplinary research environment. * Strong focus on data quality, reproducibility, and rigorous documentation. Required Education & Certifications * Doctorate (PhD) or equivalent experience in oncology, molecular biology, cellular biology, biotechnology, or translational cancer research.

Paris, France

Hybrid

11-02-2026